AT-406 HCl

Datasheet MSDS
Catalog Number
SAPO10824
Product Name
AT-406 HCl
CAS Number
1071992-57-8
Synonyms
SM-406
Molecular Formula
C32H44ClN5O4
Molecular Weight
598.19
Purity
98.0%
Solubility
DMSO: 100 mg/mL (178.02 mM) Ethanol: 100 mg/mL (178.02 mM) Water: <1 mg/mL ( < 1 mg/ml refers to the product slightly soluble or insoluble )
Storage
Powder: -20°C for 3 years In solvent: -80°C for 6 months
Description
AT-406, an orally active antagonist of multiple inhibitor of apoptosis proteins(IAP), inhibits progression of human ovarian Y binding to XIAP-BIR3, cIAP1-BIR3 and cIAP2-BIR3 with Ki of 66.4 nM, 1.9 nM, and 5.1 nM, 50- to 100-fold higher affinities than the Smac AVPI peptide.
Target
Apoptosis protein, cIAP1-BIR3, cIAP2-BIR3, XIAP-BIR3
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