Dacomitinib

Datasheet MSDS
Catalog Number
SEGF10226
Product Name
Dacomitinib
CAS Number
1110813-31-4
Synonyms
PF-299804, PF-00299804, PF299
Molecular Formula
C24H25ClFN5O2
Molecular Weight
469.94
Purity
100.00%
Solubility
1eq. HCl: 47 mg/mL (100 mM) DMSO: 47 mg/mL (100 mM) ( < 1 mg/ml refers to the product slightly soluble or insoluble )
Storage
Powder: -20°C for 3 years In solvent: -80°C for 6 months
Description
Dacomitinib (PF299804) is a potent, irreversible pan-ErbB inhibitor that acts most effectively on EGFR, IC50 is Chemicalbook6nM, and acts efficiently on NSCLCs carrying EGFR or ERBB2 mutant (anti-Gefitinib) and EGFRT790M mutant. Phase2。
Target
EGFR, HER2/ErbB2
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