Avagacestat

Datasheet MSDS
Catalog Number
SGAM25637
Product Name
Avagacestat
CAS Number
1146699-66-2
Synonyms
BMS-708163 , BMS-708163
Molecular Formula
C20H17ClF4N4O4S
Molecular Weight
520.88
Purity
98.87%
Solubility
DMSO: 96 mg/mL (184.3 mM) Ethanol: <1 mg/mL Water: <1 mg/mL ( < 1 mg/ml refers to the product slightly soluble or insoluble )
Storage
Powder: -20°C for 3 years In solvent: -80°C for 6 months
Description
Avagacestat (BMS-708163) is a potent, selective, orally bioavailable γ-secretase inhibitor of Aβ40 and Aβ42 with IC50 of 0.3 nM and 0.27 nM, demonstrating a 193-fold selectivity against Notch. Phase 2.
Target
γ secretase(Aβ40), γ secretase(Aβ42)
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