XL413 hydrochloride

Datasheet MSDS
Catalog Number
SCDK11948
Product Name
XL413 hydrochloride
CAS Number
1169562-71-3
Synonyms
XL413 , BMS-863233 , BMS-863233 Hydrochloride , XL413 , BMS-863233 Hydrochloride , BMS-863233
Molecular Formula
C14H13Cl2N3O2
Molecular Weight
326.18
Purity
99.92%
Solubility
DMSO: 10mM ( < 1 mg/ml refers to the product slightly soluble or insoluble )
Storage
Powder: -20°C for 3 years In solvent: -80°C for 6 months
Description
XL-413 is an orally bioavailable cell division cycle 7 homolog (CDC7) kinase inhibitor with potential antineoplastic activity. CDC7 kinase inhibitor BMS-863233 binds to and inhibits the activity of CDC7, which may result in the inhibition of DNA replication and mitosis, the induction of tumor cell apoptosis, and the inhibition of tumor cell proliferation in CDC7-overexpressing tumor cells. CDC7, a serine-threonine kinase overexpressed in a variety of tumor cell types, plays an essential role in the initiation of DNA replication by activating origins of replication.
Target
Cdc7, CK2, Pim1
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