AG 126

Datasheet MSDS
Catalog Number
SCOX17484
Product Name
AG 126
CAS Number
118409-62-4
Synonyms
Tyrphostin AG126
Molecular Formula
C10H5N3O3
Molecular Weight
215.17
Purity
98.72%
Solubility
DMSO: 100 mg/mL (464.75 mM), Need ultrasonic and warming ( < 1 mg/ml refers to the product slightly soluble or insoluble )
Storage
Powder: -20°C for 3 years In solvent: -80°C for 6 months
Description
The tyrphostin AG-126 selectively inhibits the phosphorylation of ERK1 (p44) and ERK2 (p42) at 25-50 μM. It blocks the production of TNF-α in vitro2 and in vivo, attenuating signaling through NF-κB, the induced expression of COX-2 and iNOS, and the inflammatory response in diverse animal models. AG-126 weakly inhibits epidermal GFRK (IC50: 450 μM) and platelet-derived GFRK (IC50 > 100 μM).
Target
COX-2, ERK1,2, ERK1, ERK2
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