MRT67307

Datasheet MSDS
Catalog Number
SIKB26355
Product Name
MRT67307
CAS Number
1190378-57-4
Synonyms
MRT67307 HCl
Molecular Formula
C26H36N6O2
Molecular Weight
464.62
Purity
99.79%
Solubility
DMSO: 83 mg/mL (178.6 mM) Ethanol: 83 mg/mL (178.6 mM) ( < 1 mg/ml refers to the product slightly soluble or insoluble )
Storage
Powder: -20°C for 3 years In solvent: -80°C for 6 months
Description
Through its effects on ULK1 and ULK2, MRT67307 blocks autophagy. MRT67307 prevents the phosphorylation of IRF3 and the production of IFN-β and increases toll-like receptor-induced IL-10 and IL-1ra secretion in macrophages. MRT67307 is a kinase inhibitor that has been shown to inhibit TBK1, MARK1-4, IKKε, and NUAK1 (IC50 values are 19, 27-52, 160, and 230 nM, respectively), the salt-inducible kinases (SIKs; IC50s =250, 67, and 430 nM for SIK1, SIK2, and SIK3, respectively) and ULK1 and ULK2 (IC50s = 45 and 38 nM, respectively).
Target
IKKϵ, TBK1
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