LY2811376

Datasheet MSDS
Catalog Number
SBAC24965
Product Name
LY2811376
CAS Number
1194044-20-6
Molecular Formula
C15H14F2N4S
Molecular Weight
320.36
Purity
99.77%
Solubility
DMSO: 13 mg/mL (40.6 mM) Ethanol: 60 mg/mL (187.3 mM) Water: <1 mg/mL ( < 1 mg/ml refers to the product slightly soluble or insoluble )
Storage
Powder: -20°C for 3 years In solvent: -80°C for 6 months
Description
LY2811376, an orally available non-peptidic β-secretase(BACE1) inhibitor (IC50: 239-249 nM), can decrease Aβ secretion (EC50: 300 nM). It has 10-fold selectivity towards BACE1 over BACE2, and more than 50-fold inhibition over other aspartic proteases including pepsin, cathepsin D, or renin.
Target
Aβ, BACE1
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