Brigatinib

Datasheet MSDS
Catalog Number
SALK10023
Product Name
Brigatinib
CAS Number
1197953-54-0
Synonyms
AP-26113
Molecular Formula
C29H39ClN7O2P
Molecular Weight
584.09
Purity
99.93%
Solubility
DMSO: Insoluble Water: Insoluble ( < 1 mg/ml refers to the product slightly soluble or insoluble )
Storage
Powder: -20°C for 3 years In solvent: -80°C for 6 months
Description
Brigatinib (AP26113) is a potent and selective ALK inhibitor with IC50=0.6 nM; Also an ROS1 inhibitor, IC50=0.9 nM. It also inhibits IGF-1R, FLT3, FLT3(D835Y) and EGFR with relatively low potency.
Target
ALK, EGFR (C797S/del19), FLT3, IGF-1R, ROS1
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