WZ3146

Datasheet MSDS
Catalog Number
SEGF10220
Product Name
WZ3146
CAS Number
1214265-56-1
Molecular Formula
C24H25ClN6O2
Molecular Weight
464.95
Purity
98.95%
Solubility
DMSO: 86 mg/mL (185 mM) Ethanol: <1 mg/mL Water: <1 mg/mL ( < 1 mg/ml refers to the product slightly soluble or insoluble )
Storage
Powder: -20°C for 3 years In solvent: -80°C for 6 months
Description
WZ3146 is a mutationally selective, irreversible EGFR (L858R) and EGFR (E746_A750) inhibitor with IC50 of 2 nM and 2 nM, respectively; There is no inhibitory effect on ERBB2 phosphorylation (T798I).
Target
EGFR (E746_A750), EGFR (E746_A750/T790M), EGFR (L858R), EGFR (L858R/T790M)
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