URMC099

Datasheet MSDS
Catalog Number
SBCR10082
Product Name
URMC099
CAS Number
1229582-33-5
Synonyms
URMC 099, URMC-099, URMC-099 URMC 099
Molecular Formula
C27H27N5
Molecular Weight
421.54
Purity
99.32%
Solubility
Ethanol: 6 mg/mL (14.2 mM) DMSO: 75 mg/mL (177.9 mM) Water: <1 mg/mL ( < 1 mg/ml refers to the product slightly soluble or insoluble )
Storage
Powder: -20°C for 3 years In solvent: -80°C for 6 months
Description
URMC - 099 is a kind of biological effective oral, brain permeability mixedlineagekinase (MLK) inhibitor, on MLK1, MLK2, ChemicalbookMLK3, and IC50 of DLK 19 nm, respectively, 42 nm, 14 nm and 150 nm, It also inhibited LRRK2 activity with IC50 of 11nM.
Target
Abl1, Aurora A, Aurora B, Aurora C, CDK1, CDK2, c-Met, DLK, IGF-1R, Insulin Receptor, Lck, LRRK2, MEKK2, MLK1, MLK2, MLK3, ROCK1, ROCK2, SGK, SGK1, Syk, TrkA, TrkB, VEGFR1/FLT1
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