Catalog Number
SCAS20782
Product Name
PF-5006739
CAS Number
1293395-67-1
Molecular Formula
C22H22FN7O
Molecular Weight
419.45
Storage
Powder: -20°C for 3 years In solvent: -80°C for 6 months
Description
PF-5006739 is an effective and selective inhibitor of CK1δ/ε (IC50s: 3.9 nM and 17.0 nM, respectively). PF-5006739 is a potential therapeutic agent for a range of psychiatric disorders with low nanomolar in vitro potency for CK1δ/ε and high kinome selectivity. PF-5006739 improves glucose tolerance in both diet-induced obesity (DIO) and genetic (ob/ob) mice models of obesity. PF-5006739 decreases opioid drug-seeking behavior in a rodent operant reinstatement model in animals in a dose-dependent manner.
Target
CK1δ CK1ϵ
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