Rociletinib

Datasheet MSDS
Catalog Number
SEGF10217
Product Name
Rociletinib
CAS Number
1374640-70-6
Synonyms
AVL-301, CNX-419, CO-1686
Molecular Formula
C27H28F3N7O3
Molecular Weight
555.55
Purity
99.25%
Solubility
DMSO: 93 mg/mL (167.4 mM) Ethanol: <1 mg/mL Water: <1 mg/mL ( < 1 mg/ml refers to the product slightly soluble or insoluble )
Storage
Powder: -20°C for 3 years In solvent: -80°C for 6 months
Description
Rociletinib (CO-1686, AVL-301) is an irreversible, mutationally selective EGFR inhibitor that acts on EGFRL858R/T790M and EGFRWT, Ki 21.5 nM and 303.3 nM, respectively. Phase 2. Target: EGFR (L858R/T790M) EGFR (wt) IC50：21.5 nM(Ki) 303.3 nM(Ki)
Target
EGFR (L858R/T790M), EGFR (wt)
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