SR9009

Datasheet MSDS
Catalog Number
SAUT11608
Product Name
SR9009
CAS Number
1379686-30-2
Synonyms
Stenabolic , REV-ERB Agonist II
Molecular Formula
C20H24ClN3O4S
Molecular Weight
437.94
Purity
99.80%
Solubility
DMSO: 43.8 mg/mL (100 mM) ( < 1 mg/ml refers to the product slightly soluble or insoluble )
Storage
Powder: -20°C for 3 years In solvent: -80°C for 6 months
Description
SR9009, a REV-ERB agonist, increases the constitutive repression of genes regulated by REV-ERBα/ERBβ (IC50: 670/800 nM). Through activation of REV-ERB, SR9009 can decrease circadian locomotor activity during the dark phase and alter the expression pattern of core clock genes in the hypothalami of mice. The circadian pattern of expression of an array of metabolic genes in the liver, skeletal muscle, and adipose tissue was also altered in mice exposed to SR9009, resulting in increased energy expenditure. In Diet-induced obese mice, SR9009 (100 mg/kg, i.p., b.i.d., for 30 days) could decrease fat mass and markedly improve dyslipidemia and hyperglycemia.
Target
Rev-ErbBα, Rev-ErbBβ
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