Crenigacestat

Datasheet MSDS
Catalog Number
SGAM25619
Product Name
Crenigacestat
CAS Number
1421438-81-4
Synonyms
LY3039478
Molecular Formula
C22H23F3N4O4
Molecular Weight
464.44
Purity
97.36%
Solubility
DMSO: 34 mg/mL Water: <1 mg/mL ( < 1 mg/ml refers to the product slightly soluble or insoluble )
Storage
Powder: -20°C for 3 years In solvent: -80°C for 6 months
Description
LY3039478 is an orally bioavailable Notch inhibitor with an IC50 of ~1 nM in most of the tumor cell lines tested. LY3039478 effectively inhibits mutant Notch receptor activity. In a xenograft tumor model, LY3039478 inhibited expression of Notch-regulated genes and N1ICD cleavage in the tumor microenvironment.
Target
Notch-1
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