Apimostinel

Datasheet MSDS
Catalog Number
RP0081
Product Name
Apimostinel
Structure
Apimostinel
CAS Number
1421866-48-9
Synonyms
NRX-1074; NRX 1074; NRX1074; AGN-241660; AGN241660; AGN 241660. Apimostinel;(2R)-1-[(2S)-1-[(2S,3R)-2-amino-3-hydroxybutanoyl]pyrrolidine-2-carbonyl]-N-[(2S,3R)-1-amino-3-hydroxy-1-oxobutan-2-yl]-2-benzylpyrrolidine-2-carboxamide
Molecular Formula
C25H37N5O6
Molecular Weight
503.6
Appearance
Powder
Purity
98%
Solubility
Soluble in DMSO
Storage
-20°C Freezer
Description
Apimostinel is a selective partial agonist of an allosteric site of the glycine site of the NMDA receptor complex under investigation by Naurex. Its mechanism of action and effects are similar to those of rapastinel. But Apimostinel is 100-fold more potent by weight and, unlike rapastinel (which must be administered via intravenous injection), is orally-active. Phase II clinical trials for the treatment of Major depressive disorder is on-going.
SMILES
CC(C(C(=O)N1CCCC1C(=O)N2CCCC2(CC3=CC=CC=C3)C(=O)NC(C(C)O)C(=O)N)N)O
InChI
InChI=1S/C25H37N5O6/c1-15(31)19(26)23(35)29-12-6-10-18(29)22(34)30-13-7-11-25(30,14-17-8-4-3-5-9-17)24(36)28-20(16(2)32)21(27)33/h3-5,8-9,15-16,18-20,31-32H,6-7,10-14,26H2,1-2H3,(H2,27,33)(H,28,36)/t15-,16-,18+,19+,20+,25-/m1/s1
InChI Key
DVBUEXCIEIAXPM-PJUQSVSOSA-N
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