TAK-243

Datasheet MSDS
Catalog Number
A16974
Product Name
TAK-243
Structure
TAK-243
CAS Number
1450833-55-2
Synonyms
MLN7243
Molecular Formula
C19H20F3N5O5S2
Molecular Weight
519.52
Purity
98.80%
Solubility
DMSO: 50 mg/mL (96.24 mM), Need ultrasonic H2O: 1 mg/mL (1.92 mM), Need ultrasonic ( < 1 mg/ml refers to the product slightly soluble or insoluble )
Storage
Powder: -20°C for 3 years In solvent: -80°C for 6 months
Description
TAK-243 is a small molecule inhibitor of ubiquitin-activating enzyme (UAE ,IC50=1 nM), which blocks ubiquitin conjugation, disrupting monoubiquitin signaling as well as global protein ubiquitination. TAK-243 (MLN7243) induces endoplasmic reticulum (ER) stress, abrogates NF-κB pathway activation and promotes apoptosis,with potential antineoplastic activity.
Target
UBA1
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