SAR405

Datasheet MSDS
Catalog Number
A12831L
Product Name
SAR405
Structure
SAR405
CAS Number
1523406-39-4
Molecular Formula
C19H21ClF3N5O2
Molecular Weight
443.85
Purity
99.79%
Solubility
DMSO: 27 mg/mL (60.83 mM) ( < 1 mg/ml refers to the product slightly soluble or insoluble )
Storage
Powder: -20°C for 3 years In solvent: -80°C for 6 months
Description
SAR-405 is a potent and selective PIK3C3/Vps34 inhibitor (IC50:1.2 nM; Kd:1.5 nM) that prevents autophagy and synergizes with MTOR inhibition in tumor cells. SAR405 treatment also inhibits autophagy induced either by starvation or by MTOR (mechanistic target of rapamycin) inhibition. Combining SAR405 with everolimus results in a significant synergy on the reduction of cell proliferation using renal tumor cells.
Target
Vps34 Autophagy
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