Catalog Number
SALK10054
Product Name
TPX0005
CAS Number
1802220-02-5
Synonyms
TPX 0005, TPX-0005, Repotrectinib
Molecular Formula
C18H18FN5O2
Molecular Weight
355.37
Purity
100.00%
Solubility
DMSO: 83.3 mg/mL ( < 1 mg/ml refers to the product slightly soluble or insoluble )
Storage
Powder: -20°C for 3 years In solvent: -80°C for 6 months
Description
Repotrectinib (TPX-0005) is a novel ALK/ROS1/TRK inhibitor with IC50 of 1.01 nM, 1.26 nM and 1.08 nM against WT ALK, ALK(G1202R) and ALK(L1196M), respectively. It is also an effective SRC inhibitor with an IC50 of 5.3 nM.
Target
ALK, Src
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