Catalog Number
SBCL10876
Product Name
BDA366
CAS Number
1821496-27-8
Synonyms
BDA 366 , BDA-366
Molecular Formula
C24H29N3O4
Molecular Weight
423.26
Purity
99.14%
Solubility
DMSO: 84 mg/mL (198.34 mM) Ethanol: 5 mg/mL (11.8 mM) Water: <1 mg/mL ( < 1 mg/ml refers to the product slightly soluble or insoluble )
Storage
Powder: -20°C for 3 years In solvent: -80°C for 6 months
Description
BDA-366 specifically targets the BH4 domain of Bcl2 BDA-366 and suppresses human myeloma growth. BDA-366 induces robust apoptosis in MM cell lines and primary MM cells by inducing BCL2 conformational change. Delivery of BDA-366 substantially suppressed the growth of human MM xenografts in NOD-scid/IL2Rγnull mice, without obvious effects on normal hematopoietic cells or body weight.
Target
Bcl-2-BH4
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