Desmethylanethol trithione

Datasheet MSDS
Catalog Number
SVEG10763
Product Name
Desmethylanethol trithione
CAS Number
18274-81-2
Synonyms
ADT-OH
Molecular Formula
C9H6OS3
Molecular Weight
226.33
Purity
98.23%
Solubility
DMSO: 10 mM ( < 1 mg/ml refers to the product slightly soluble or insoluble )
Storage
Powder: -20°C for 3 years In solvent: -80°C for 6 months
Description
Desmethylanethol trithione is a derivative of anethole dithiolethione (ADT) and synthetic hydrogen sulfide (H2S) donor. In the in vitro glucose-oxygen deprivation (OGD) model, ADT-OH markedly attenuated tPA-enhanced Akt activation and VEGF expression in brain microvascular endothelial cells. Finally, ADT-OH improved functional outcomes in mice subjected to MCAO and tPA infusion. H2S donors reduced tPA-induced cerebral hemorrhage by possibly inhibiting the Akt-VEGF-MMP9 cascade. Administration of H2S donors has potential as a novel modality to improve the safety of tPA following the stroke.
Target
Akt, VEGFR
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