Ilorasertib hydrochloride

Datasheet MSDS
Catalog Number
SAUR11851
Product Name
Ilorasertib hydrochloride
CAS Number
1847485-91-9
Synonyms
ABT-348 hydrochloride
Molecular Formula
C25H22ClFN6O2S
Molecular Weight
525
Solubility
DMSO: 41.67 mg/mL (79.37 mM), Need ultrasonic ( < 1 mg/ml refers to the product slightly soluble or insoluble )
Storage
Powder: -20°C for 3 years In solvent: -80°C for 6 months
Description
Ilorasertib hydrochloride (ABT-348 hydrochloride) is an ATP-competitive multitargeted kinase inhibitor, which inhibits Aurora C, Aurora B, and Aurora A (IC50s: 1 nM, 7 nM, 120 nM). It also suppresses RET tyrosine kinase, PDGFRβ, and Flt1 (IC50s: 7 nM, 3 nM, and 32 nM).
Target
Aurora C, Aurora B, Aurora B (Y156H), Aurora A, PDGFRα, PDGFRβ, VEGFR1, VEGFR2, VEGFR3, FLT3, CSF-1R, c-KIT
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