Roscovitine

Datasheet MSDS
Catalog Number
SCDK11872
Product Name
Roscovitine
CAS Number
186692-46-6
Synonyms
CYC202 , R-roscovitine , Seliciclib
Molecular Formula
C19H26N6O
Molecular Weight
354.45
Purity
100.00%
Solubility
Ethanol: 6 mg/mL (16.92 mM) DMSO: 71 mg/mL (200.31 mM) Water: <1 mg/mL ( < 1 mg/ml refers to the product slightly soluble or insoluble )
Storage
Powder: -20°C for 3 years In solvent: -80°C for 6 months
Description
Roscovitine is a potent inhibitor of Cdk2/cyclin E (IC50: 0.1 µM). It also inhibits Cdk7/cyclin H, Cdk5/p35, and Cdc2/cyclin B (IC50s: 0.49/0.16/0.65 µM).
Target
Cdc2/CyclinB, CDK2/CyclinA, CDK2/CyclinE, CDK5/p35, ERK2
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