Tetrahydrouridine

Datasheet MSDS
Catalog Number
SDNA12570
Product Name
Tetrahydrouridine
CAS Number
18771-50-1
Synonyms
THU , NSC-112907 , NSC112907 , NSC-112907 , NSC 112907 , NSC 112907
Molecular Formula
C9H14N2O6
Molecular Weight
246.22
Solubility
Water: Insoluble DMSO: 10mg/mL (40.29mM) ( < 1 mg/ml refers to the product slightly soluble or insoluble )
Storage
Powder: -20°C for 3 years In solvent: -80°C for 6 months
Description
Tetrahydrouridine (THU) is a multidrug resistance modulator. It can be used in cancer treatment to make tumor cells more sensitive to radiation therapy. THU is a competitive cytidine deaminase(CDA) inhibitor that inhibits deamination in the catabolism of cytotoxic deoxycytidine analogs such as ara-C and Gemcitabine.
Target
cytidine deaminase (CDA)
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