Lazertinib

Datasheet MSDS
Catalog Number
SEGF10189
Product Name
Lazertinib
CAS Number
1903008-80-9
Synonyms
GNS-1480, YH25448, Lazertinib (YH25448), YH25448, Lazertinib (YH25448), GNS-1480
Molecular Formula
C30H34N8O3
Molecular Weight
554.64
Purity
99.96%
Solubility
Ethanol: Insoluble Water: Insoluble DMSO: 10 mg/mL ( < 1 mg/ml refers to the product slightly soluble or insoluble )
Storage
Powder: -20°C for 3 years In solvent: -80°C for 6 months
Description
Lazertinib (YH25448, GNS-1480) is a potent, highly selective, irreversible EGFR inhibitor with IC50s for Del19/T790M, L858R/T790M, Del19, L85R, and wild-type EGFR at 1.7 nM, 2 nM, 5 nM, 20.6 nM, and 76 nM, respectively. IC50 values are higher for ErbB2 and ErbB4.
Target
L858R/T790M EGFR, WT EGFR
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