Wortmannin

Datasheet MSDS
Catalog Number
SATM14128
Product Name
Wortmannin
CAS Number
19545-26-7
Synonyms
KY-12420 , SL-2052 , SL-2052 KY-12420
Molecular Formula
C23H24O8
Molecular Weight
428.43
Purity
99.76%
Solubility
DMSO: 21.4 mg/mL (50 mM) Ethanol: 2.1 mg/mL (5 mM)), with gentle warming ( < 1 mg/ml refers to the product slightly soluble or insoluble )
Storage
Powder: -20°C for 3 years In solvent: -80°C for 6 months
Description
Wortmannin is the first described PI3K inhibitor with IC50 of 3 nM, with little selectivity within the PI3K family. Also blocks autophagosome formation and potently inhibits DNA-PK/ATM with IC50 of 16 nM and 150 nM.
Target
PI3K , DNA-PK , ATM , MLCK , ATR, DNA-PK, ATM
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