LY411575

Datasheet MSDS
Catalog Number
SGAM25621
Product Name
LY411575
CAS Number
209984-57-6
Molecular Formula
C26H23F2N3O4
Molecular Weight
479.48
Purity
99.38%
Solubility
DMSO: 88 mg/mL (183.5 mM) Ethanol: 11 mg/mL (22.9 mM) Water: <1 mg/mL ( < 1 mg/ml refers to the product slightly soluble or insoluble )
Storage
Powder: -20°C for 3 years In solvent: -80°C for 6 months
Description
LY411575, a potent γ-secretase inhibitor, is with IC50 of 0.078 nM in the membrane and 0.082 nM in cell-based. It also suppresses Notch clevage with IC50 of 0.39 nM.
Target
Notch S3 cleavage, γ secretase (cell-based), γ secretase (membrane-based)
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