Ensartinib dihydrochloride

Datasheet MSDS
Catalog Number
SALK10031
Product Name
Ensartinib dihydrochloride
CAS Number
2137030-98-7
Synonyms
X-396 dihydrochloride, X-396 dihydrochloride
Molecular Formula
C26H29Cl4FN6O3
Molecular Weight
634.36
Purity
99.29%
Solubility
DMSO: 100 mg/ml (157.64 mM) Water: 27 mg/ml (42.56 mM) Water: 27 mg/ml (42.56 mM) DMSO: 33mg/ml (52.02 mM) ( < 1 mg/ml refers to the product slightly soluble or insoluble )
Storage
Powder: -20°C for 3 years In solvent: -80°C for 6 months
Description
Ensartinib dihydrochloride is a potent new-generation ALK inhibitor with high activity against CNS metastases and a broad range of known crizotinib-resistant ALK mutations. It potently inhibits both wild-type ALK and ALK variants (C1156Y, F1174, G1202R, L1196M, S1206R, and T1151 mutants) with in vitro IC50s of <4 nM.
Target
ALK, ALK variants, GOPC-ROS1, TPM3-TRKA, TRKC
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