Tosedostat

Datasheet MSDS
Catalog Number
SAMI20524
Product Name
Tosedostat
CAS Number
238750-77-1
Synonyms
CHR-2797 , CHR-2797
Molecular Formula
C21H30N2O6
Molecular Weight
406.47
Purity
99.40%
Solubility
DMSO: >10 mM ( < 1 mg/ml refers to the product slightly soluble or insoluble )
Storage
Powder: -20°C for 3 years In solvent: -80°C for 6 months
Description
CHR-2797 is an orally bioavailable inhibitor of the M1 family of aminopeptidases with potential antineoplastic activity. CHR-2797 is converted intracellularly into a poorly membrane-permeable active metabolite (CHR-79888) which inhibits the M1 family of aminopeptidases, particularly puromycin-sensitive aminopeptidase (PuSA), and leukotriene A4 (LTA4) hydrolase; inhibition of these aminopeptidases in tumor cells may result in amino acid deprivation, inhibition of protein synthesis due to a decrease in the intracellular free amino acid pool, an increase in the level of the proapoptotic protein Noxa, and cell death.
Target
M1-aminopeptidase
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