Canertinib dihydrochloride

Catalog Number
SEGF10182
Product Name
Canertinib dihydrochloride
CAS Number
289499-45-2
Synonyms
CI-1033 dihydrochloride, PD-183805 dihydrochloride, Canertinib
Molecular Formula
C24H27Cl3FN5O3
Molecular Weight
558.86
Purity
99.23%
Solubility
DMSO: 55.9 mg/mL (100 mM) ( < 1 mg/ml refers to the product slightly soluble or insoluble )
Storage
Powder: -20°C for 3 years In solvent: -80°C for 6 months
Description
Canertinib (CI-1033, PD-183805, compound 18) dihydrochloride is an effective and irreversible inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase. Canertinib dihydrochloride inhibits cell EGFR and ErbB2 autophosphorylation with IC50 values of 7.4 nM and 9 nM, respectively.
Target
EGFR, HER2/ErbB2
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