Apcin

Datasheet MSDS
Catalog Number
SAPC11809
Product Name
Apcin
CAS Number
300815-04-7
Molecular Formula
C13H14Cl3N7O4
Molecular Weight
438.65
Purity
96.74%
Solubility
DMSO: 240 mg/mL (547.13 mM), Need ultrasonic ( < 1 mg/ml refers to the product slightly soluble or insoluble )
Storage
Powder: -20°C for 3 years In solvent: -80°C for 6 months
Description
Apcin is a potent and competitive inhibitor of anaphase-promoting complex/cyclosome (APC/C(Cdc20)) E3 ligase activity. Apcin competitively inhibits APC/C-dependent ubiquitylation by binding to Cdc20 and preventing substrate recognition. It acts by blocking mitotic exit and being synergistically amplified by co-addition of Ts-Arg-OMe.
Target
Others, Cdc20
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