SB 431542

Datasheet MSDS
Catalog Number
SALK10005
Product Name
SB 431542
CAS Number
301836-41-9
IUPAC Name
4-[4-(1,3-benzodioxol-5-yl)-5-pyridin-2-yl-1H-imidazol-2-yl]benzamide
Molecular Formula
C22H16N4O3
Molecular Weight
384.39
Appearance
White Solid
Purity
100.00%
Density
1.373 g/cm3
Solubility
DMSO: 38.4 mg/mL (100 mM) Ethanol: 3.8 mg/mL (10 mM) ( < 1 mg/ml refers to the product slightly soluble or insoluble )
Melting Point
214 °C (dec.)
Boiling Point
662.4±55.0 °C (Predicted)
Storage
Powder: -20°C for 3 years In solvent: -80°C for 6 months
Description
SB431542 is a potent, selective ALK5 inhibitor with an IC50 of 94 nM in cell-free trials and a 100-fold stronger activity against ALK5 than against P38, MAPK and other kinases.
SMILES
C1OC2=C(O1)C=C(C=C2)C3=C(NC(=N3)C4=CC=C(C=C4)C(=O)N)C5=CC=CC=N5
InChI
InChI=1S/C22H16N4O3/c23-21(27)13-4-6-14(7-5-13)22-25-19(20(26-22)16-3-1-2-10-24-16)15-8-9-17-18(11-15)29-12-28-17/h1-11H,12H2,(H2,23,27)(H,25,26)
InChI Key
FHYUGAJXYORMHI-UHFFFAOYSA-N
Target
ALK5, ALK4
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