Clozapine N-oxide

Datasheet MSDS
Catalog Number
S5HT15564
Product Name
Clozapine N-oxide
CAS Number
34233-69-7
Molecular Formula
C18H19ClN4O
Molecular Weight
342.82
Purity
99.94%
Solubility
Ethanol: 10 mg/mL Water: 1 mg/mL DMSO: 6 mg/mL ( < 1 mg/ml refers to the product slightly soluble or insoluble )
Storage
Powder: -20°C for 3 years In solvent: -80°C for 6 months
Description
Clozapine N-oxide is a major metabolite of clozapine that can be detected in the earliest excretion time interval after clozapine administration [1]. It is produced by the action of cytochrome P450 (CYP) isoforms CYP1A2 and CYP3A4, whose activities, in turn, can be affected by drugs and disease [2]. Clozapine N-oxide is normally biologically inactive. However, it can be used in designer receptor exclusively activated by designer drugs, also known as DREADDs, technology to modulate synthetic receptors in vivo [3].
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