SB525334

Datasheet MSDS
Catalog Number
SALK10004
Product Name
SB525334
CAS Number
356559-20-1
IUPAC Name
6-[2-tert-butyl-5-(6-methylpyridin-2-yl)-1H-imidazol-4-yl]quinoxaline
Synonyms
TGF-β RI Kinase Inhibitor VIII
Molecular Formula
C21H21N5
Molecular Weight
343.42
Appearance
A crystalline solid
Purity
99.86%
Density
1.191 g/cm3
Solubility
1eq. HCl: 34.3 mg/mL (100 mM) DMSO: 34.3 mg/mL (100 mM) ( < 1 mg/ml refers to the product slightly soluble or insoluble )
Melting Point
159 °C
Boiling Point
540.5±45.0 °C (Predicted)
Storage
Powder: -20°C for 3 years In solvent: -80°C for 6 months
Description
SB525334 is an effective and selective TGFβ receptor I (ALK5) inhibitor with IC50 of 14.3 nM. The effect of acting on ALK4 is 4 times lower than that of ALK5, and can inhibit ALK2, 3, and 6 activities.
SMILES
CC1=NC(=CC=C1)C2=C(N=C(N2)C(C)(C)C)C3=CC4=NC=CN=C4C=C3
InChI
InChI=1S/C21H21N5/c1-13-6-5-7-16(24-13)19-18(25-20(26-19)21(2,3)4)14-8-9-15-17(12-14)23-11-10-22-15/h5-12H,1-4H3,(H,25,26)
InChI Key
DKPQHFZUICCZHF-UHFFFAOYSA-N
Target
TGFβR1(ALK5), ALK5, ALK4
Inquiry

new products