Mubritinib

Datasheet MSDS
Catalog Number
SEGF10181
Product Name
Mubritinib
CAS Number
366017-09-6
Synonyms
TAK-165, TAK-165
Molecular Formula
C25H23F3N4O2
Molecular Weight
468.47
Purity
99.86%
Solubility
DMSO: 35.1 mg/mL (75 mM) ( < 1 mg/ml refers to the product slightly soluble or insoluble )
Storage
Powder: -20°C for 3 years In solvent: -80°C for 6 months
Description
Mubritinib (TAK 165) is a potent HER2/ErbB2 inhibitor with AN50 of 6 nM in BT-474 cells; In the BT-474 cell line, there is no inhibitory effect on EGFR, FGFR, PDGFR, JAK1, Src and Blk. Phase 1。
Target
EGFR, FGFR, HER2/ErbB2, JAK1, PDGFR
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