Semagacestat

Datasheet MSDS
Catalog Number
SGAM25626
Product Name
Semagacestat
CAS Number
425386-60-3
Synonyms
LY450139 , LY450139
Molecular Formula
C19H27N3O4
Molecular Weight
361.44
Purity
99.11%
Solubility
DMSO: 67 mg/mL (185.4 mM) Ethanol: 39 mg/mL (107.9 mM) Water: <1 mg/mL ( < 1 mg/ml refers to the product slightly soluble or insoluble )
Storage
Powder: -20°C for 3 years In solvent: -80°C for 6 months
Description
Semagacestat (LY450139) is a γ-secretase blocker for Aβ42/Aβ40/Aβ38 (IC50: 10.9/12.1/12.0 nM) and also inhibits Notch signaling (IC50: 14.1 nM).
Target
Notch, γ secretase(Aβ38), γ secretase(Aβ40), γ secretase(Aβ42)
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