NU6140

Datasheet MSDS
Catalog Number
SAUR11850
Product Name
NU6140
CAS Number
444723-13-1
Molecular Formula
C23H30N6O2
Molecular Weight
422.52
Purity
98.04%
Solubility
DMSO: 250 mg/mL (591.69 mM), Need ultrasonic ( < 1 mg/ml refers to the product slightly soluble or insoluble )
Storage
Powder: -20°C for 3 years In solvent: -80°C for 6 months
Description
NU6140 is a selective inhibitor of CDK2-cyclin A (IC50, 0.41 μM). It shows 10- to 36-fold selectivity over other CDKs. NU6140 also effectively inhibits Aurora A and Aurora B (IC50s: 67 and 35 nM, respectively). It also enhances the apoptotic effect and has anti-cancer activity.
Target
cdk2-cyclin A, CDK1-Cyclin B, CDK4-Cyclin D, cdk5-p25, cdk7-cyclin H, Aurora A, Aurora B
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