RepSox

Datasheet MSDS
Catalog Number
SALK10009
Product Name
RepSox
CAS Number
446859-33-2
IUPAC Name
2-[5-(6-methylpyridin-2-yl)-1H-pyrazol-4-yl]-1,5-naphthyridine
Synonyms
SJN 2511, E-616452, ALK5 Inhibitor II, SJN 2511, E-616452 ALK5 Inhibitor II
Molecular Formula
C17H13N5
Molecular Weight
287.32
Appearance
Crystalline Solid
Purity
98.57%
Density
1.296±0.06 g/cm3 (Predicted)
Solubility
DMSO: 53 mg/mL (184.5 mM) Ethanol: <1 mg/mL Water: <1 mg/mL ( < 1 mg/ml refers to the product slightly soluble or insoluble )
Melting Point
195 °C
Boiling Point
501.9±50.0 °C (Predicted)
Storage
Powder: -20°C for 3 years In solvent: -80°C for 6 months
Description
RepSox (E-616452, SJN 2511, ALK5 Inhibitor II) is a potent, selective TGFβR-1/ALK5 Inhibitor that binds ATP to ALK5 and autophosphorates ALK5 with IC50 of 23 nM and 4 nM in cell-free assay.
SMILES
CC1=NC(=CC=C1)C2=C(C=NN2)C3=NC4=C(C=C3)N=CC=C4
InChI
InChI=1S/C17H13N5/c1-11-4-2-5-16(20-11)17-12(10-19-22-17)13-7-8-14-15(21-13)6-3-9-18-14/h2-10H,1H3,(H,19,22)
InChI Key
LBPKYPYHDKKRFS-UHFFFAOYSA-N
Target
ALK5, TGFβR1
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