GW 788388

Datasheet MSDS
Catalog Number
SALK10008
Product Name
GW 788388
CAS Number
452342-67-5
IUPAC Name
N-(oxan-4-yl)-4-[4-(5-pyridin-2-yl-1H-pyrazol-4-yl)pyridin-2-yl]benzamide
Molecular Formula
C25H23N5O2
Molecular Weight
425.48
Appearance
A crystalline solid
Purity
98.79%
Density
1.34 g/cm3
Solubility
DMSO: 42.6 mg/mL (100 mM) ( < 1 mg/ml refers to the product slightly soluble or insoluble )
Storage
Powder: -20°C for 3 years In solvent: -80°C for 6 months
Description
GW788388 is a potent, selective ALK5 inhibitor with an IC50 of 18 nM that also inhibits other TGF-βI and II receptor kinases, but does not inhibit BMP II receptors.
SMILES
C1COCCC1NC(=O)C2=CC=C(C=C2)C3=NC=CC(=C3)C4=C(NN=C4)C5=CC=CC=N5
InChI
InChI=1S/C25H23N5O2/c31-25(29-20-9-13-32-14-10-20)18-6-4-17(5-7-18)23-15-19(8-12-27-23)21-16-28-30-24(21)22-3-1-2-11-26-22/h1-8,11-12,15-16,20H,9-10,13-14H2,(H,28,30)(H,29,31)
InChI Key
SAGZIBJAQGBRQA-UHFFFAOYSA-N
Target
ALK5
Inquiry

new products