AEE788

Datasheet MSDS
Catalog Number
SBCR10066
Product Name
AEE788
CAS Number
497839-62-0
Synonyms
NVP-AEE 788
Molecular Formula
C27H32N6
Molecular Weight
440.58
Purity
100.00%
Solubility
DMSO: 82 mg/mL (186.1 mM) Ethanol: <1 mg/mL ( < 1 mg/ml refers to the product slightly soluble or insoluble )
Storage
Powder: -20°C for 3 years In solvent: -80°C for 6 months
Description
AEE788 (NVP-AEE788) is a potent EGFR and HER2/ErbB2 inhibitor, IC50 is 2nM and 6nM, respectively, has a slightly weaker effect on VEGFR2/KChemicalbookDR, c-Abl, c-Src, and Flt-1, and has no inhibitory effect on Ins-R, IGF-1R, PKCα and CDK1. Phase1/2。
Target
c-Abl, c-Fms, EGFR, FLT1, HER2/ErbB2
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