Fludrocortisone acetate

Datasheet MSDS
Catalog Number
SAUT11639
Product Name
Fludrocortisone acetate
CAS Number
514-36-3
Synonyms
9α-Fluorcortisol acetate , 9α-Fludrocortisone acetate , 9α-fluorocortisol acetate
Molecular Formula
C23H31FO6
Molecular Weight
422.5
Purity
97.60%
Solubility
DMSO: 10 mM ( < 1 mg/ml refers to the product slightly soluble or insoluble )
Storage
Powder: -20°C for 3 years In solvent: -80°C for 6 months
Description
Fludrocortisone, a glucocorticoid-receptor agonist, binds to cytoplasmic receptors, translocates to the nucleus, and subsequently initiates the transcription of glucocorticoid-responsive genes such as lipocortins to inhibit phospholipase A2 (PLA2). Fludrocortisone Acetate is the acetate salt of a synthetic fluorinated corticosteroid with anti-inflammatory and antiallergic activities. Inhibition of PLA2 activity prevents the release of arachidonic acid, a precursor of eicosanoids such as prostaglandins and leukotrienes; eicosanoids are important mediators in the pro-inflammatory response mechanism. As a mineralocorticoid-receptor agonist, this agent stimulates Na+ reabsorption and water retention and K+ and H+ secretion in the distal tubules and collecting ducts of the kidney.
Target
Others
Inquiry

new products