Mexiletine hydrochloride

Datasheet MSDS
Catalog Number
SAHR17297
Product Name
Mexiletine hydrochloride
CAS Number
5370-01-4
Synonyms
KOE-1173 (hydrochloride) , Mexiletine HCl , KO1173
Molecular Formula
C11H18ClNO
Molecular Weight
215.72
Purity
99.90%
Solubility
DMSO: 21.6 mg/mL (100 mM) water: 21.6 mg/mL (100 mM) ( < 1 mg/ml refers to the product slightly soluble or insoluble )
Storage
Powder: -20°C for 3 years In solvent: -80°C for 6 months
Description
Mexiletine Hydrochloride is the hydrochloride salt form of mexiletine, a local anesthetic and antiarrhythmic (Class IB) agent structurally related to lidocaine. Mexiletine exerts its antiarrhythmic effect by inhibiting the inward sodium current in cardiac cells, thereby reducing the rate of rising of the cardiac action potential (phase 0) and decreases automaticity in the Purkinje fibers. This slows nerve impulses in the heart and stabilizes the heartbeat. Mexiletine's anesthetic activity is due to its ability to block sodium influx in peripheral nerves, thereby reducing the rate and intensity of pain impulses reaching the central nervous system.
Target
AhR, Voltage-gated sodium channel
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