Busulfan

Datasheet MSDS
Catalog Number
SDNA14178
Product Name
Busulfan
CAS Number
55-98-1
Synonyms
Myleran , Busulphan , Sulphabutin
Molecular Formula
C6H14O6S2
Molecular Weight
246.3
Purity
99.77%
Solubility
DMSO: 46 mg/mL (186.8 mM) Ethanol: <1 mg/mL ( < 1 mg/ml refers to the product slightly soluble or insoluble )
Storage
Powder: -20°C for 3 years In solvent: -80°C for 6 months
Description
Busulfan is a synthetic derivative of dimethane-sulfonate with antineoplastic and cytotoxic properties. Although its mechanism of action is not fully understood, busulfan appears to act through the alkylation of DNA. Following systemic absorption of busulfan, carbonium ions are formed, resulting in DNA alkylation and DNA breaks and inhibition of DNA replication and RNA transcription.
Target
DNA Alkylation
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