SB 297006

Datasheet MSDS
Catalog Number
SCCR17366
Product Name
SB 297006
CAS Number
58816-69-6
Molecular Formula
C18H18N2O5
Molecular Weight
342.4
Purity
99.65%
Solubility
H2O: < 0.1 mg/mL (insoluble) DMSO: 150 mg/mL (438.15 mM), Need ultrasonic ( < 1 mg/ml refers to the product slightly soluble or insoluble )
Storage
Powder: -20°C for 3 years In solvent: -80°C for 6 months
Description
SB 297006 is an antagonist of C-C chemokine receptor 3 (CCR3; IC50 = 39 nM), which normally is activated by eotaxin, eotaxin-3, MCP-3, MCP-4, RANTES, and MIP-1δ. It is at least 250-fold selective for CCR3 over a panel of other chemokine receptors. SB 297006 blocks CCR3-mediated calcium mobilization induced by eotaxin, eotaxin-2, and MCP-4 in transfected cells. It suppresses antigen-induced accumulation of Th2 lymphocytes and eosinophils in lungs of mice when delivered subcutaneously (100 mg/kg).
Target
CCR3
Inquiry

new products