Firibastat

Datasheet MSDS
Catalog Number
SAMI20519
Product Name
Firibastat
CAS Number
648927-86-0
Synonyms
QGC 001 , RB 150 , QGC001 , RB150 , RB-150 , QGC-001
Molecular Formula
C8H20N2O6S4
Molecular Weight
368.51
Solubility
H2O: 30mg/mL (81.41mM), Need ultrasonic ( < 1 mg/ml refers to the product slightly soluble or insoluble )
Storage
Powder: -20°C for 3 years In solvent: -80°C for 6 months
Description
QGC-001 is a glutamyl aminopeptidase antagonist and an orally active brain penetrating prodrug of EC33. It is a first-in-class brain aminopeptidase A (APA) inhibitor with a Ki of 200 nM. QGC-001 selectively and specifically inhibits conversion of brain angiotensin-II into angiotensin-III and decreases blood pressure in hypertensive rats[1][2].
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