Neratinib

Datasheet MSDS
Catalog Number
SEGF10166
Product Name
Neratinib
CAS Number
698387-09-6
Synonyms
HKI-272
Molecular Formula
C30H29ClN6O3
Molecular Weight
557.04
Purity
100.00%
Solubility
DMSO: 6 mg/mL (10.8 mM) Ethanol: <1 mg/mL Water: <1 mg/mL ( < 1 mg/ml refers to the product slightly soluble or insoluble )
Storage
Powder: -20°C for 3 years In solvent: -80°C for 6 months
Description
Neratinib (HKI-272) is a highly selective HER2 and EGFR inhibitor with IC50s of 59nM and 92nM, respectively, in cell-free assays. Weak chemical book KDR and Src did not have significant inhibitory effects on Akt, CDK1/2/4, IKK-2, MK-2, PDK1, c-Raf and c-Met. Phase3。
Target
EGFR, HER2, PDK1, Src, VEGFR2 (KDR)
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