A-3 hydrochloride

Datasheet MSDS
Catalog Number
SPKC13351
Product Name
A-3 hydrochloride
CAS Number
78957-85-4
Molecular Formula
C12H14Cl2N2O2S
Molecular Weight
321.22
Purity
99.79%
Solubility
DMSO: 125 mg/mL (389.14 mM), Need ultrasonic ( < 1 mg/ml refers to the product slightly soluble or insoluble )
Storage
Powder: -20°C for 3 years In solvent: -80°C for 6 months
Description
A-3 hydrochloride is a potent, cell-permeable, reversible, ATP-competitive non-selective antagonist of various kinases. A-3 hydrochloride also inhibits PKC and casein kinase I with Ki values of 47 µM and 80 µM, respectively[1]. A-3 hydrochloride against PKA (Ki=4.3 µM), casein kinase II (Ki=5.1 µM) and myosin light chain kinase (MLCK) (Ki=7.4 µM).
Target
CK1, CK2, PKC, PKA
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