Cilastatin

Datasheet MSDS
Catalog Number
SPRO27940
Product Name
Cilastatin
CAS Number
82009-34-5
Synonyms
MK0791
Molecular Formula
C16H26N2O5S
Molecular Weight
358.45
Purity
99.71%
Solubility
DMSO: 10 mM ( < 1 mg/ml refers to the product slightly soluble or insoluble )
Storage
Powder: -20°C for 3 years In solvent: -80°C for 6 months
Description
Cilastatin is a renal dehydropeptidase-I and leukotriene D4 dipeptidase inhibitor. Since the antibiotic, IMIPENEM, is hydrolyzed by dehydropeptidase-I, which resides in the brush border of the renal tubule, cilastatin is administered with imipenem to increase its effectiveness. The drug also inhibits the metabolism of leukotriene D4 to leukotriene E4.
Target
Dipeptidase 1
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