Catalog Number
SBCR10068
Product Name
GNF7
CAS Number
839706-07-9
Synonyms
GNF 7, GNF-7
Molecular Formula
C28H24F3N7O2
Molecular Weight
547.53
Purity
99.00%
Solubility
DMSO: 16 mg/mL (29.2 mM) Ethanol: <1 mg/mL Water: <1 mg/mL ( < 1 mg/ml refers to the product slightly soluble or insoluble )
Storage
Powder: -20°C for 3 years In solvent: -80°C for 6 months
Description
GNF-7 is a multi-kinase inhibitor. GNF-7 is an inhibitor of Bcr-Abl, and the IC50 values for the effects of Bcr-AblWT and Bcr-AblT315I are 133nM and 61nM, respectively. GNF-7 also has inhibitory activity against ACK1 and GCK, IC50 is 25nM and 8nM, respectively. GNF-7 can be used in the study of hematologic malignancies.
Target
c-Abl, E255V, G250E, M351T, T315I
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