Sapitinib

Datasheet MSDS
Catalog Number
SEGF10202
Product Name
Sapitinib
CAS Number
848942-61-0
Synonyms
AZD-8931, AZD-8931
Molecular Formula
C23H25ClFN5O3
Molecular Weight
473.93
Purity
99.83%
Solubility
DMSO: 38 mg/mL (80.2 mM) Ethanol: <1 mg/mL Water: <1 mg/mL ( < 1 mg/ml refers to the product slightly soluble or insoluble )
Storage
Powder: -20°C for 3 years In solvent: -80°C for 6 months
Description
Sapitinib (AZD8931) is a reversible, ATP competitive EGFR, ErbB2 and ErbB3 inhibitor, IC50 in cell-free assays are 4nM, 3nM and 4ChemicalbooknM, acting on NSCLC cells more effectively than Gefitinib or Lapatinib, acting on the ErbB family is 100 times more selective than acting on MNK1 and Flt. Phase2。
Target
EGFR, HER2/ErbB2
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