AT101 acetate

Datasheet MSDS
Catalog Number
SBCL10886
Product Name
AT101 acetate
CAS Number
866541-93-7
Synonyms
(-)-Gossypol acetic acid , (R)-Gossypol acetic acid , (R)-(-)-Gossypol acetic acid , AT-101 (acetic acid) , AT101 , AT101 , AT-101 (acetic acid) , (R)-Gossypol acetic acid , (R)-(-)-Gossypol acetic acid (-)-Gossypol acetic acid
Molecular Formula
C30H30O8·C2H4O2
Molecular Weight
578.61
Purity
99.50%
Solubility
DMSO: 107 mg/mL (184.9 mM) Ethanol: 82 mg/mL (141.7 mM) Water: <1 mg/mL ( < 1 mg/ml refers to the product slightly soluble or insoluble )
Storage
Powder: -20°C for 3 years In solvent: -80°C for 6 months
Description
AT101, the R-(-) enantiomer of Gossypol acetic acid, binds with Bcl-2, Bcl-xL and Mcl-1 with Ki of 0.32 μM, 0.48 μM and 0.18 μM; does not inhibit BIR3 domain and BID. Phase 2.
Target
Bcl-2, Bcl-xL, Mcl-1
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